You can go a long way with just 3D printing a mould in PLA and then just filling it with silicone. I've done some parts this way, and haven't felt the need to use mould release for either the silicone from the mould, or the resulting glass reinforced epoxy parts from the silicone. Not for body use in my case.
I modeled some plastic parts as a meta-mould to make a mould for some parts I wanted to make.