Do you mind sharing some? Most websites I can think of are either highly distributed (e.g. Facebook, Netflix) or their customer base is geographically limited (Yelp).

Uploading media files to (or from) developing countries with weaker internet infra often results in timeouts and dropped connections. I tried uploading a 8GB file to Singapore S3 from Florida and my connection often timed out.

I'm trying to imagine how you can deliver a fast website to users around the globe without distributed systems.