It's not the performance per se, that doesn't really matter for Python's use cases, it's that the performance charateristics of your program are so erratic it doesn't feel like the pieces are fitting together. Denotationally equivalent operations having drastically diverging operational interpretations means that changing anything is a nightmare.
If you have an API call that does what you want, Python is basically C++. If you don't, you're paying a 100x penalty.
Most of the times performance doesn't matter, and when it doesn't, life is great. When it does matter, the situation feels worse than it actually is because optimizing Python is such a fight.