Sure! I use a single toolbar at the top that contains back/forward, refresh/stop, menu dropdowns (which are all hidden except for History/Bookmarks/Tools), the address bar, my bookmarks toolbar buttons, and all addon buttons. Below that is my tab toolbar. This setup is accomplished by CSS with a bunch of position:absolute; and negative margins and stuff, because it's impossible to truly have all of these things in the same toolbar physically. Every single time they change stuff, it gets screwed up.
Prior to their rewrite of everything in version fifty-whatever, I could just drag-and-drop all this stuff into a single toolbar, but when they decided they knew better than me how I want my browser to look it all got 100x harder to get the layout I want.
In addition to this single-toolbar layout I have some easy stuff like highlighting the background color of "View background image" and "Copy link location" and I think 2-3 other things in the context menu a dark purple so that I misclick less often (this particular change is actually amazing and I highly recommend it!).
And I make the URL dropdown suggestions constrained to the width of the URL bar, not 100%, because I find the context switching of hiding the entire webpage too jarring when they're that wide. And I also hide a bunch of random buttons here and there that I find useless; I'm not sure what they are at this point because they've been hidden for so long...
Oh! And my highlight color (in URL bar, etc) is bright magenta (otherwise my theme is dark mode). Just because I like it. :) I use that in Sublimetext too, though I don't do that in every text editor/IDE.