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Nigerians have lots of APOE4 (a gene that leads to much higher rates of alzheimers), and really low cholesterol. And they also have lower rates of AD.

I think base on current evidence your family might just have great cholesterol genes and bad AD genes.

Btw how old was your father, aunt and grandmother when they got AD?

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Dad's 85. He was 82 when it became clear he was having significant problems, but mom had been saying he was having lesser problems before that. My aunt has just turned 80. Grandma died at 87. I'm not sure exactly when she became symptomatic, but it was also around 80. I'm 53. I figure I have 20-25 good years left.

The cholesterol connection is of interest because of my family history, but my current thinking is that the so-called Type 3 Diabetes pathway seems very plausible. Whether it affects brain health or not, I'm on the "carbs are bad" bandwagon.

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