I'm not sure what you're arguing in terms of acceptable risk. Biotech is incredibly regulated, specifically because the risks are so high, effectively there is very little acceptable risk. In biotech, a patient dying due to your drug is a Big Problem that will at best cause you to put a disclaimer on the package (see Black Box Warning) and at worst immediately end your drug's prospects. We can argue about trade-offs (if you've got terminal cancer, maybe a rare heart event is a worthwhile risk, probably less so if you have a rash), but this is exactly the way it should be.

Self driving cars are a nice luxury, especially in city driving, not something that radically improves our world. You get to read your phone instead of paying attention, and the trade-off is someone might get killed. It's like treating a rash with a drug that could give you a heart attack. That's a far cry from, "with this technology something that took days and $$$$ now takes hours and $" as was the case with all the older examples you listed.

If self driving cars were more like airplanes, I'd have a little more faith. Tesla's marketing BS doesn't inspire me with lots of faith.

On black boxes: https://health.clevelandclinic.org/what-does-it-mean-if-my-m...