There are deep and rigorously rational and ethical reasons to be against the current vaccine narratives promulgated by this administration. It's ignorant and disingenuous to dismiss the arguments as equivalent to the "vaccines are made of mercury, cause autism, the lord is my vaccine,etc" single digit iq cretins.
It got politicized because apparently both parties decided it was OK to fuck with America's pandemic response, because it justifies expansion of power and control. Never let a crisis go to waste.