If Framework opens this up for other companies to make modules, you might also see something like a USB port module with an integrated Logitech wireless mouse receiver. So then your mouse isn't even taking up a port.

I know Bluetooth is a thing but you get the point. All of those tiny devices that people keep plugged into their laptop ports 24/7? This is a much better form factor for them, and you don't necessarily need to sacrifice a port for them either.