WireGuard encrypted UDP packets have obvious signature due to the packet type field in the header being in cleartext. DPI can easily filter/drop WG traffic just by checking the first few bytes of each UDP packet and doing simple statistics.
To obfuscate in this context means to morph WireGuard encrypted UDP packets to look like something else (e.g. VoIP traffic).
Current kernel-based official WireGuard implementations leave no possibility of doing so while staying in-kernel.