Another issue I'm thinking is that I don't know the state of the art of meteor/bolide trajectory estimation (it's apparently very poor), so you'd probably need to fire a bunch of these (or a very large one) along an (uncertain) path hoping for it to affect the impactor.
So this is just more of the same problem: how do you fire a barrage of nuclear missiles over a region to stop an impactor in such a way that you're not mistaken for a madman starting nuclear war?