The technological choices are the obvious ones. Should we build on this platform or that one? They're probably not the highest priority in the grand scheme, but their effects are also most systematically underestimated, I think.
As technologies add leverage the same number of people can do more. So you can get away with hiring less, and run less risk of needing to close down divisions. Or you can raise less money and run less risk of too-many-cooks syndrome in the boardroom.
I'm sure these considerations are more obvious in small internet startups that are struggling to get off the ground. My point was just that you don't need quite the same amount of courage as before because at least a few life-or-death decisions have been taken off the table.