Nuclear proliferation is like our training wheels for all the dangerous techs that are to come. If you are worried about it, look into how world governance works, how international norms are agreed on, and take a partisan stance against the parties that block the ability to do such things.

Nuclear proliferation: so far so good.

Ozone layer destruction: disaster adverted

CO2 limitations: we would have solved that by now without GWB suddenly deciding that disbelieving in climate change was now a respectable policy position.

> The destruction that nuclear weapons can cause is nothing compared to the potential destruction from self-replicating machines

I think you overestimate the speed at which this will come. We probably could, today, make a self replicating machine from raw materials but it would be the size of a factory and would have a replication cycle of a few months. Going from self-replication to grey-goo will take some time, hopefully we can prepare to it.