I've been remote a loooong time and that's always been the case. I miss out on so many 'oh, because Timmy in the SOC told me so' type things, spontaneous whiteboards, and much information. It certainly makes things a bit more complicated. Further, I found it harder to get promotions in general.

All in all, I still prefer it despite its drawbacks. But it's certainly not for everyone, especially people who get or had little social interaction outside of work, and those who are chasing ladder climbing.