It's natural for a touch interface: each word made up of scrabble-like tiles with a letter on each, tap the letter(s) from each word that spell out the answer and submit for a score. Or, if you wanted to get crazy, you could play heads-up, but you'd need a whole lot of clues/answers lined up if you wanted to go that route (so if you wanted to go really crazy, string together some databases and programs to auto-generate each puzzle).