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Comment by dabbledash | Hacker News Reader

As you can see from some previous replies, it’s because people are less concerned with what’s true than with how (they believe) information will influence the behavior of others.

The apparent prevalence of this attitude in media and public health is eroding the credibility of those institutions, imo.

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Agreed, it's very much an attempted form of manipulation by hardcore pro-vaccine people. There's a line of logic among anti-vaxxers of "I'll take my chances", and studies like these -- which show that taking your chances with COVID, surviving (which might be overwhelmingly likely), and then going on your merry way gives you equal or greater protection than the vaccine. Hardcore pro-vaxxers would much rather the narrative be "the vaccine, and only the vaccine, will protect you."

Sort of like when the FDA insinuates that Ivermectin is unsafe because it has also been used by veterinarians in addition to its human indications.

“You are not a horse. You are not a cow. Seriously y’all. Stop it.”

FDA… You approved the drug for use in humans and it has less side effects than acetaminophen / paracetamol… y’all.

That was bs from the FDA, but it’s ok because the folksy “y’all” is endearing to who I assume they were internally calling ”flyover hicks self-medicating with horse paste”.

All they had to say was we have not approved this medication for covid and the animal applications are not approved for use in humans, their dosages can be very dangerous.

Off-topic but does anyone have a mechanism by which Ivermectin would be helpful with Coronavirus? It seems bizarre that an anti-parasite medicine targeting a eukaryote would have any efficacy against a virus.

I'll give you one (total supposition, I Am Not A Veterinarian): most people don't "get infected" with worms, but some have exposure and have immune responses that may not ever rise to the level of "symptoms". anti-parasitcs might assist and allow more robust responses to other health challenges.

Don't look too deep into how much life we host even when healthy; it'll squick you out.

So far a multitude of randomized clinical trials (RCTs) have tried but not found significant benefits from using Ivermectin to treat COVID-19 in a single-drug treatment regime.

However it's worth noting that certain multi-drug treatment regimes are looking quite promising [1][2].

Furthermore, early multi-drug treatment (before severe symptoms) using existing widely available medicines has been proven effective at reducing hospitalization and death [3][4][5][6][7]. Many front-line doctors have been using such techniques since the beginning of the pandemic, because they had to - as there were no vaccines yet and no RCTs to guide them so naturally the only option was using and combining existing medicines with established safety and efficacy profiles, the same strategy used for other difficult to treat diseases and cancers.

[1] Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial https://pubmed.ncbi.nlm.nih.gov/33983065/

[2] Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 https://pubmed.ncbi.nlm.nih.gov/33306283/

[3] Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.1...

[4] Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection https://rcm.imrpress.com/EN/article/downloadArticleFile.do?a...

[5] Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residents https://www.sciencedirect.com/science/article/abs/pii/S03069...

[6] Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) https://scholarlycommons.henryford.com/cgi/viewcontent.cgi?a...

[7] Multidrug treatment for COVID-19 https://www.jstage.jst.go.jp/article/ddt/advpub/0/advpub_202...

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