I have often wondered if there are easy ways to invest easily on a 'patch'ed index fund, for example, NASDAQ_100 sans Uber. Of course one can buy the individual stocks in the patched index in the same proportions but that's going to be very expensive in terms of transaction costs (and general headache).

@danhak For some reason I cant respond to you. I had put/call options in mind but shorting/longing would work.