I recently watched a short mini-doc about Notch, of minecraft fame, and it seems he really went through it after selling MC for $2.5 billion. He talked a lot about isolation and an inability to connect with other people, despite becoming well known for insane parties and stating he has the ability to do whatever he wants.

Other people who have come upon sudden riches have expressed the same sentiment. There was a great post on reddit years ago from a guy in wealth management who talked about the severe lack of "human experience" when you achieve maximum wealth.