I wonder if it is worth it to select a few core libraries like glibc, and get the distro to install multiple variants, each optimized for a different CPU.
(edit) Even though i'm a sucker for efficiency/performance, i prefer Tumbleweed myself. Since i like KDE, whose integration is as good as it gets on SUSE but left a lot to be desired on Clear which ships with GNOME by default. Both are rolling releases. SUSE has automatic btrfs snapshots on updates for easy rollback. But Clear has the performance edge.
https://www.phoronix.com/scan.php?page=article&item=ubuntu-2...
https://www.phoronix.com/scan.php?page=article&item=cascade-...
https://www.phoronix.com/scan.php?page=article&item=icelake-...
Oh nice this one shows Tumbleweed is not far behind:
https://www.phoronix.com/scan.php?page=article&item=amd-epyc...