Yeah. I did a lot of work with blood measures and every disease had some characteristic spike in n immune function. I worked in a lab with a ton of immunologists and we never knew what was going on. All we could say was activation of complement or strong TNF response or something else descriptive but not really helpful. Just too much dark matter in the immune system. My big hope is that the silver lining of COVID will be a much deeper understanding of the immune system. Certainly a ton of money is being poured into it. Fingers crossed, we could be entering a golden age for immuno-therapeutics.