At least here in Europe there are laws (for commercial drivers) about how long you are allowed to drive for, and when you must take breaks, e.g.:
> "you must not drive more than: 9 hours in a day - this can be extended to 10 hours twice a week"
> "a break or breaks totalling at least 45 minutes after no more than 4 hours 30 minutes driving"
Perhaps the US has zero laws in this regard, but these sort of rules exist due to lots of lessons learned by tired drivers killing people. Sure these are for commercial drivers, but I'd argue that if you are doing this sort of long-distance driving frequently (i.e. not just once or twice a year) then you are no different from a commercial driver and shouldn't assume these common sense laws don't apply.