In the case of gauge theory, the idea that we should consider the most general case has been well proven. As GP pointed out, all observable phenomena ultimately depend only on the absolute modulus of the field Ψ, so a theoretical physicist naturally wonders, what happens if you allow its complex phase to vary. Turns out nothing interesting happens if you apply a global phase, but if you allow the phase to vary at every point in spacetime, it ends up breaking the theory. That is, unless you include an additional field at every point in spacetime that precisely cancels out the change induced by the gauge freedom.
In other words, the motivation is that we can't simply look and "see" whether or not there is a locally varying phase on the wavefunction Ψ, since we only can measure |Ψ|^2. So we have to assume there is, until proven otherwise. Since a local phase would imply the existence of an extra field to cancel it out, we can indirectly check for this scenario by looking for the corresponding field. As pointed out by GP, in the case of a U(1) gauge, it turns out there is such a field, and electromagnetism (and all of its laws) exactly fit the bill.
There are other "unmeasurable" symmetries you could apply to the wave function as well, beyond just a complex phase. SU(2) is a Lie group symmetry which would mean that the measurable properties of certain tuples of fields (Ψ, ϕ) are indistinguishable under a sort of complex-valued rotation of Ψ->ϕ and ϕ->Ψ. Again, if you assume a such symmetry is locally varied at every point in spacetime, you end up requiring not one but three new fields to cancel out the effects on the SM Lagrangian. It turns out that the vector bosons W+, W-, and Z, which mediate weak nuclear forces exactly fit the bill.