Or were you really just meaning to advocate for metaprogramming in general?
In this system, I write a given function in C and surround it with a macro wrapper. This wrapper generates a JSON-RPC equivalent of the C function using the Jansson JSON library [1], complete with argument typechecking and error management. My C code can call the function normally, and an embedded webserver [2] can export it across the network where it's used fairly transparently by a Python stack on a control PC.
All three of these "embedded software" elements (the embedded webserver, the JSON library, and the FPGA interface) are very well suited to C. I have recently dabbled in moving parts of it to C++, and have found a few surprising impedance mismatches. (As I mentioned above, C++ still lacks reflection.)
The macros, here, are not for "elegance" or any other abstract purpose. They have allowed a ~80% reduction in boilerplate and an equally impressive reduction in the bugs and hassles associated with this kind of low-density, high-sprawl code.