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No idea about doom, but Starcraft 2 works for me fine.

SC2 works almost perfectly under Wine/Proton.

Only issue is that a few custom maps crash, and there's a weird, minor performance issue at some point in the LOTV campaign menus (but not the game itself). Haven't had an issue in a ladder game in years. And I play SC2 a lot (too much).

"Almost" is the key word here, under a VFIO VM, it's 100% flawless.

I recently finished the single player campaign on Doom Eternal - that worked perfect, though i havent tried multiplayer.