First seems reasonable. I've not heard of anything on the later coming even close credibly - though is an obvious holy grail.
For example, see [1] or [2], and [2] was spun off into a company (Neoleukin Therapeutics).
[1] https://science.sciencemag.org/content/371/6531/eabc8182 [2] https://www.nature.com/articles/s41586-018-0830-7