Not according to historians [0]. The definition of genocide is [1]:
genocide means any of the following acts committed with intent to destroy, in whole or in part, a national, ethnical, racial or religious group
From [0]:
Witnesses testified that his brief government of Hispaniola was marked by routine cruelty not only to the native Taínos but also to Spaniards who defied or mocked him.
Columbus wanted living and multiplying subjects to tax and govern. He was not interested in depopulating newly acquired territories.
[0] https://www.washingtonpost.com/opinions/five-myths-about-chr...