Mirtazapine (atypical antidepressant) helped me for about 2 years, but then it was downhill from there. Gained 60 lbs on 200 (27 on 91). It's used in certain cases for people to gain weight.
When it worked, it was amazing, but the weight gain was intolerable. Missing a single dose felt exactly like a hangover after sleeping.
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In this age, I would say:
- exercise even more
- subject yourself to more cold (burn more calories)
- subject yourself to more heat (suppress appetite)
- fasting - alternate day
- fasting - 18.6
- organic as much as possible
- eliminate industrially-processed foods as much as possible: if it comes in a box, it's probably suspect.
- eliminate plastic containers
- take the stairs rather than the elevator
- modify one's route to deliberately walk more
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Another thing that needs to happen is for food packages to be wax, glass, or other materials for containers that don't contaminate the food with plastic compounds.