You wouldn't ask the question if you had developed both GUI apps on MS stack with VS and web apps: the MS dev experience is very good, while the web one is meh at best. C# vs JS, XAML vs HTML+CSS (debatable), desktop application model vs web one, VS vs whatever else, there is a lot of strong arguments in favor of the MS stack in that case.

Microsoft is trying to port some of this magic with Blazor, with is quite liked from what I read here and there.