I think you already said it. The long life (high reliability) requirement, and I'll add the complexity of having it unfold. Both of those become non-issues if you build the telescope right into a space-X starship. There may be other issues with that, but the mirror wouldn't need to fold ;-)
Additionally, the engineering requirements for long-term life support are significantly more involved than the Dragon capsule.
There's also the testing and certification process for crewed-missions; in non-Elon time, this is likely several years, conservatively speaking [1]. (I'd love to be proven wrong, however!).
[0] https://www.space.com/spacex-starship-super-heavy-booster-ro...
[1] https://arstechnica.com/science/2021/04/five-reasons-why-nas...