When I was on an SSRI to deal with anxiety this was the biggest change. I wouldn't say I was suddenly cocky or free of doubt, but I didn't dwell on my choices or worry about how others received me. I was quickly able waive away any self-doubt instead of ruminating on it for days or weeks:

Did I make the right call on this project? Will I get fired if I made the wrong decision? Oh well, a decision had to be made and I made the best one I could.

Someone is having a bad day that I care about? That is on them, not on me.

I suppose SSRI made me a bit of a sociopath, but at the same time it was freeing and allowed me to be happier, more productive,outgoing, friendly, and generally just more all around likable. People gravitated towards me more because I was indifferent and friendly, rather than friendly, but seeking approval.

My empathy towards others was slowly killing me. I cared too much about everything. Like most things, empathy is probably a spectrum. Too much and you are paralyzed with emotions and fear, too little and you are a sociopath who doesn't regard others. I guess in my case I still had empathy as I didn't start screwing people over for personal gain or anything, but I wasn't going to let myself get run over by someone else out of respect for their feelings either.

There is a reason most business leaders are described as being sociopaths; they probably are close to that end of the spectrum. If you are worried about everyone else's feelings all of the time it will probably hold you back in the business world, but you can take solace in that you are a good person who cares about others.