The page lists these uses for 128-computing, any of which seem like sufficient motivators for it to come to pass:

  - The free software used to implement RISC-V architecture is defined for 32, 64 and 128 bits [...]
  - Universally unique identifiers (UUID) consist of a 128-bit value.
  - IPv6 routes computer network traffic amongst a 128-bit range of addresses.
  - ZFS is a 128-bit file system.
  - 128 bits is a common key size for symmetric ciphers [...]
  - The IBM i virtual instruction set defines all pointers as 128-bit.
  - Increasing the word size can speed up multiple precision mathematical libraries [...]
  - MD5 is a hash function producing a 128-bit hash value.
  - Apache Avro uses a 128-bit random number as synchronization marker [...]