Usually with esoteric distros you run into problems with binary packages and packages based on uncommonly used languages.
It'll probably work as a daily driver if you mainly live in a web browser and don't do GPGPU/games/new languages/etc. If you don't mind building from source you can even do most of those.
For what it's worth the project seems very well structured and the contributors very competent and motivated. I am tracking the project.