Presumably there is some unknown process which either favors matter production or sequesters antimatter as this occurred during the big bang.
The apparatus would need to immediately separate the two to prevent an extremely large explosion.
1kg of mass to energy (assuming every single particle met a corresponding antiparticle) would release a little over half the energy of the Krakatoa volcano eruption, similar to a 21 megaton bomb, so around the upper end of fusion bombs. Helium is about 99.5% the mass of the hydrogen that goes into it, so I guess those big fusion bombs must produce about 200kg of helium?
either way super cool
(megaton, to be clear, is not a measure of mass when talking about bombs, it's a measure of energy released - a 1 megaton bomb is equivalent to the energy released by a million tons of TNT, if such a volume could be detonated)