I keep wishing someone would take C#'s concept of dynamic references and run with it.
Optional static typing, like what you get in Typescript or MyPy, is interesting, but defaulting to dynamic and making static opt-in undermines a lot of the potential benefit of static typing. I don't think that it works the other way around, though. My hunch, which I am not particularly prepared to defend, is that, at least as long as you've got good type inference, defaulting to static and making dynamic opt-in does let you keep most of the practical benefits of dynamic typing.
I guess it's kind of like unsafe code blocks, also from C#: Pointers and weak typing can be very useful in some circumstances, but I'm generally much happier having the compiler try to guarantee as much as it can, and then sometimes be able to tell it, "Nah, hang on, I got this one."