From my experience with Vyvanse I find that amphetamines have a dose response function with linear and exponential steps. 15mg is barely perceptible, 30mg is like a coffee without the anxiety but it last 8 hours. 45mg is like 30mg but a little longer. 60mg in 2 doses (first pill at 7am and next one at 9am) is a perfect treatment against my ADD. Once I tried 90mg and it was terrible, I experienced bruxism, anxiety and hyperacidity for 18 hours. I am sure that I would develop the problems you listed if I were to take 90mg a day but 90mg of Vyvanse is supratherapeutic...
1: Link 41 is about abuse (supratherapeutic and frequent doses). Link 43 I can't comment as I don't have acces but it's an old paper from 1988... Link 45 is about abuse again. Link 46 is about accidental ingestion by a baby. (a therapeutic dose for a teenager is clearly supratherapeutic in a 8months infant) Link 47 is probably about abuse (the abstract talk of reversible consequences of dose escalation) but I don't have acces to the paper.