Some things are just physics. Physics places absolute limits on how small or large an organism can be, for example. It's why I'm not worried about the possibility of superintelligent viruses.
There is a long theory of the value of thought experiments in science. The word "atom" is derived from the Greek "atomos", which was the result of a 2000+ year old thought experiment about if something was infinitely divisible or not. Experimental evidence didn't come until the 1800s (IIRC).
It seems weird that any article talking about possible alien life doesn't at least touch on the anthropic principle, which is a whole set of thought experiments.
My personal view is that our knowledge of the Universe at this point isn't perfect but it's closer to correct than not. That means (IMHO) the speed of light is an absolute limit and thermodynamics holds true.
With just those two things, you have a lot of constraints and you can start making some observations. For example: a burgeoning civilization needs energy (and matter), will produce waste heat and that waste heat has to go somewhere.
This of course touches on various thought experiments relating to the Fermi Paradox.
My personal view is that there simply aren't any starfaring civilizations to find within a pretty large (1M+ light years) light cone. And if you look at the Milky Way, if there aren't any to find now, it's highly unlikely there other civilizations beyond our light cone just because of the low probability of two (or more) such civilizations evolving to that point within 100,000 years of each other.