There's a world full of natural phenomena which we perceive dimly. We try to create linguistic structures that explain it. A proposed change to that linguistic structure, like "Fairies are real," can only be more or less helpful in explaining the world we observe.
As George Box said, "All models are wrong; some models are useful." We should always be open to possibility. I am equally open to Bigfoot, UFOs, ESP, vampires, fairies, Santa, and Thor as explanations for phenomena. Which is to say that they are historically bad explanations that can never be disproven, but which have been demonstrably unhelpful in explaining the world.