If by "anecdotal," you mean personal stories, not medical studies, that's no longer true. There are many studies comparing psychedelics with conventional treatments for depression and PTSD (eg below). Psychedelics have been repeatedly shown to work faster, 'better,' and provide longer-lasting relief than conventional treatments. Indeed, some studies selected treatment-resistant cases, so results apply to cases in which mainstream treatments have already failed.

Additional monitoring and analysis are always needed, as with any medical treatment. Depression can be a fatal illness, so avoiding effective treatment until the field is more "mature" may cost lives.

3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial https://pubmed.ncbi.nlm.nih.gov/29728331/

Psilocybin with psychological support for treatment-resistant depression: six-month follow-up https://pubmed.ncbi.nlm.nih.gov/29119217/

Here's a counter-example to my claim, FYI. Trial of Psilocybin versus Escitalopram for Depression https://www.nejm.org/doi/10.1056/NEJMoa2032994