> Ultimately the real question is, does it affect our survivability as a species.
Biology is a rich and wealthy system of evolved solutions for living on earth.
We could turn everything into people, but we'd lose so much information. Fungal growths on rocks may not seem like a lot to a layperson without appreciation, but such species took more work than the sum total human thought to arise. Killing it off is akin to burning the entire library of congress. Worse, perhaps.
We're too primitive to harness the wealth of information in our biosphere today. In a hundred years, there will be solutions in biology readily available to biochemical problems we're only beginning to characterize.
We hate that we killed the dodo and the woolly mammoth. But more than just erasing animals we learned about in childhood, and more than leaving holes in ecosystems, we destroyed the living and breathing universe solving unique and beautiful ways of dealing with itself. Solutions too complicated for humans to comprehend, and not even close to within our capacity to replicate.