I have, on macOS, and somehow, it has much much worse lag than Mitsuharu Yamamoto's Emacs "Mac port," [1] which is still based on Emacs 27.2. The native comp version was so slow that I gave up and switched back to Mitsuharu's port, which is snappy enough for my needs even without the native compilation bits.

From what I gather, mainline Emacs was adversely impacted by changes in Mojave. [2][3] The end result, for me, is that any gains in the native compilation are swamped by the macOS issues. I'm hoping that Mistuharu rebases his work on the native-comp Emacs soon, so that I can get the best of both.

[1] https://bitbucket.org/mituharu/emacs-mac/src/master/

[2] https://www.reddit.com/r/emacs/comments/faz1fm/seeing_a_flas...

[3] https://emacs.stackexchange.com/questions/59966/is-it-possib...