The natural endgame for that is to place all governmental function at the federal level.
And I find it equally weird that each separate state gets to define health care regulations, such that separate companies are required in each different state. Lots of duplicated efforts.
There are certainly some functions that are best managed locally, and I suppose there must be some value to the "laboratory of the states" notion (though there are way, way too many variables for any of these experiments to actually be informative).
But in general, yeah, there's a bunch of stuff that I'd just as soon see pushed up rather than down. It would save a lot of headaches. There is surely some stuff that could be pushed down, as well.
I grew up in southern MO. Arkansas was only about a 40 minute drive away, but I can always tell when I'm there compared to at home. The people dress and look a bit different, the houses look different, it's just a different culture. California and New York are like alien worlds to me. The idea that such different people should live under the same framework seems like a good way to amplify regional tensions.