Had a somewhat similar issue, but with Drive File Stream.

At one point I set it up to use my second SSD as the local storage. Then I needed that SSD elsewhere, so I just took it out. It was impossible to restart the damn thing. It kept complaining about missing folders. I even tried uninstalling and reinstalling it, but it kept its settings.

Since I barely used that machine, if ever, and I'm not particularly familiar with Windows, I never really looked into how to completely clean up the configuration. But the point is that there clearly are some pretty stupid decisions about some products.