If your rest interface is deeply tied to the Django DB, I'd suggest TastyPie.
Otherwise Django-Piston sadly is the way to go.
Otherwise Django-Piston sadly is the way to go.
I'm looking at ModelResource as my example.
If you aren't working with a NoSQL database or a search engine, or grabbing data from an tertiary resource then the sheer complexity found in TastyPie might not be for you.
Django-Piston doesn't offer many features, but its dead simple in its usage.