The blocker that is stopping me ordering this today (besides being in Canada) is:
1. The display. I've spent the last several years using laptops with higher resolution displays (either Macbook Pros or, more recently, a 4k Dell XPS 13), and honestly, I'm not going back. It's a shame that the one thing that doesn't seem to be upgradeable right now is the screen configuration. (I realise that the Framework's display isn't exactly low-res, but it feels like it's going to be in an uncanny valley of not quite HiDPI/Retina.)
Beyond that, other things I wish were different (or at least clearer), but which aren't blockers:
1. Like other commenters, I don't use Windows, and I don't particularly want to pay for a Windows licence. 2. There's no mention I can see on the product page of how many external displays are supported, and in what configurations, and that's important to me. 3. I'd probably be more comfortable if some late pre-production units had made it to independent reviewers for judging things like battery life and the display. (I'd love to see an Anandtech breakdown of a Framework!)