Talking about user usecases, every time I play a game on Steam. At the very least there are GNU TLS versioning problems. That's why steam packages it's own library system containing multiple versions of the same library -- thus rendering all of the benefits of shared libraries completely null.
One day, game developers will package static binaries, and the compiler will be able to rip out all of the functions that they don't use, and I won't have to have 5 - 20 copies of the same library on my system just sitting around -- worse if you have multiple steam installs in the same /home partition because you're a distro hopper.
One day...