But in many contexts biological sex is irrelevant. There's room to debate exactly what contexts -- e.g., in professional sports that are segregated by sex so that women can have competitions in which they aren't obliterated by men who are just stronger, you might want to keep people with Y chromosomes out of the women's events, or maybe you should do that by measuring testosterone levels or something. But by and large, if you aren't (1) providing medical care to someone or (2) having sex with them, you get better outcomes for everyone by paying attention to how they prefer to live than to their chromosomes when those diverge.
"But people are getting cancelled just for saying that biological sex is real!" Eh, no. But to whatever degree anything like that is happening, a key part of the reason is that it turns out that people who make a big deal about how biological sex is real almost always actually have a bigger agenda that goes way beyond affirming that biological sex is real. If e.g. you want to keep trans women out of women's public bathrooms, or make sure gender-dysphoric teenagers aren't put on puberty blockers, or not have to call someone "he" if they look more like a "she" to you -- none of those things follow from "biological sex is real".