Enhancements to primate evolutionary fitness are not much use to a machine, - Said who?
I strongly suspect that the hardest part of mind uploading won't be the mind part, but the body and its interactions with its surroundings. That's actually the easy part, the motor and sensory systems even in humans are largely deciphered.
Uploading implicitly refutes the doctrine of the existence of an immortal soul I thought this was refuted centuries ago, and anyway, it's a red herring.
our hard-wired biophilia will keep dragging us back to the real world, or to simulations indistinguishable from it Is the "real world" something stable? The same human brains performed great with both stone age cave living as well as modern megacity-life.
And so on and so on. The basic argument is "It is definately possible, but we may have reservations about it, ergo it's impossible"