I agree with you, but I think I can respond in summary instead of point-by-point:
"First: super-intelligent AI is unlikely because, if you pursue Vernor's program, you get there incrementally by way of human-equivalent AI, and human-equivalent AI is unlikely."
The arguments that follow don't say anything about why it's impossible or even prohibitively difficult to do, they only provide reasons why people wouldn't want to try. There are, however, motivations beyond those he takes into consideration.
Uploading:
Again, he doesn't make any arguments as to why uploading is not achievable, he just talks about the very hard ethical questions that arise when dealing with uploaded intelligences. That didn't stop us from inventing nuclear weapons and a host of other ethicaly challenging technologies, so why would it stop us from inventing uploading?
One particular statement he makes in this section I do want to address specifically:
"Uploading implicitly refutes the doctrine of the existence of an immortal soul, and therefore presents a raw rebuttal to those religious doctrines that believe in a life after death."
This is so obviously untrue that I don't know how any intelligent person could use it in a serious argument. Religions that believe in immortal souls will simply maintain that the uploaded copy is just that: a copy, a soulless simulation of a real person. How can you possibly prove this one way or another? "Soul" is a purely religious concept, beyond any temporal means of observation or measurement, and therefore not subject to empirical study. I still think you would see plenty of religious people oppose uploading, but for different reasons.
He finishes by discussing the possibility that our entire universe is already a simulation being run in the "real" world, and admits that nobody can prove this one way or another, at least not anytime soon.