How do you carry your monitor? this has been a problem for me during covid. also there is the work chair problem..
Oh, but chairs for me are not a problem. I have been a very happy standing-worker for 13 years now. It started with hip and lower back pain in my early 30s, which seemed f'd up, and then some articles by a Mayo Clinic doctor who worked standing and sometimes on a treadmill. Turns out, it was good advice. Now I stand all day - sometimes 18 hours, and don't even notice. (To be clear, you always move a bit, shift your weight, etc.; it's not being a statue.)
Slightly more seriously, there is no one answer. But in terms of total human history, sitting isn't something we spent a lot of time doing. Sleeping, lying flat, we obviously spend about 1/4 to 1/3 of our time doing. Standing or walking or running surely must be a big portion of the rest. Sitting would only be reserved for when you have the time to "do nothing". That's kind of a new concept. Thusly, I'm not afraid.
For a 50 year old nerd who hasn't exercised in a year, I'm still well above the health and capabilities of a lot of same age people. And when I'm in a good environment with outdoor play areas (mountain biking) or indoor gyms, I'm fit. Aesthetically, losing hair and gaining less elastic skin is much more a concern to me than some tiny purple lines in my ankles or knees :/
I think it's all a balance of sitting and standing, and not taking one to the extreme. I say this as I just threw my back out a few weeks ago, because I was sitting all day :( So yeah, I'm not a model person to listen to either!