I've picked Django because it can be run with pypy (jit python) and makes it very fast. I prefer minimizing server costs.
Those interested in a C++ web app framework might consider wt (webtoolkit). It has a built in http/https web server and is thus plug&play for average applications. It is worth a look at.
I'll use an SQL db and CPython for the MVP, but I have an open road in front of me to optimize with NoSQL, PyPy, wherever it is required.
Note that there are many other parameters to consider, like ease of programming, toolbox richness, reliability of code, etc. The choice is up to you according to your weighting of theses parameters.
Check out Alex Gaynor's slides from DjangoCon for more info here: http://alexgaynor.net/2011/jun/07/djangocon-europe-2011-slid...