Try it and see what happens.
I build secure communications solutions for a living, so I'm speaking from experience.
Any solution worth its salt doesn't want or need UPnP on your network, it doesn't need anything other than for you to let it hit the internet and for the traffic to come back the other way.
I also run and have run other solutions in my day to day working from home and private life, many SIP flavours, Teams, Zoom (once, because it was the only option), Jitsi, BBB, Google Duo, Hangouts, Houseparty they all work with no effort from me.
There is a lot of hypothetical about what will and won't work, but take it or leave it when I say that some of us, the people building these solutions, have a bit of a clue about networking and how to build solutions around security best-practice.
I also game online with PC, Nintendo Switch and PlayStation 4/5, not one has given me issues, nor have I needed any custom firewall rules for the consoles.
My wife works from home on a government issues laptop, she's never complained of issues with video conferencing or her work VPN.
There may be some exceptions, sure, but it's less of an issue than people think.